Rinse whole lettuce leaves and pat dry, being careful not tear them. Set aside.
In a medium skillet over medium-high heat, brown the ground beef, stirring often; drain. Remove from pan and set aside.
Cook the onion in the same pan, stirring frequently, until soft and tender.
Add the garlic, soy sauce, hoisin sauce, ginger, vinegar, and chile pepper sauce to the onions; stir.
Stir in chopped water chestnuts, green onions, and sesame oil, and continue cooking until the onions just begin to wilt, about 2 minutes.
Arrange lettuce leaves around the outer edge of a large serving platter, and pile meat mixture in the center.
To serve, allow each person to spoon a portion of the meat into a lettuce leaf. Wrap the lettuce around the meat like a burrito, and enjoy!